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KMID : 0384119930130030373
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Korean Journal of Clinical Pathology
1993 Volume.13 No. 3 p.373 ~ p.380
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A Case of Chronic Neutrophilic Leukemia
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이성희
최태윤/김원배/이동화/강득용/원종호/박희숙
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Abstract
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Chronic neutrophilic leukemia is a rare form of myeloproliferative disorder. It is characterized by sustained neutrophilia with splenomegaly in the absence of fever, inflammation or any detectable cause for a leukemoid reaction, and laboratory
findings
show elevated neutrophil alkaline phosphatase(NAP), serum vitamin B12 and serum uric acid, and negative Philadelphia chromosome. Authors experienced a case of chronic neutrophilic leukemia in a 53-year-old man, evolving to the stage of blast
crisis. WBC
count of the peripheral blood was 68.600/μL with 76% segmented neutrophils. The underlying disease for a leukemoid reaction had not been detectod. NAP score and the serum levels of vitamin B12 and uric acid were elevated. Bone marrow aspiration
revealed marked myeloid hyperplasia with 32% of mature neutrophils. Chromosomc study showed a normal karyotype without Philadelphia chromosome or rearrangement within breakpoint cluster region(bcr). Four months after the stage of remission, the
hematological picture evolved into a blast crisis of myeloid features (myeloblast 24%, promyelecyte 13%).
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